Computations in Science Seminars
Dec 2021
1
Wed 12:15
Madhav Mani, Northwestern University
Host: William Irvine ()
Organizer: Kabir Husain ()
A Statistical (Physics) view of Organismal Development

After a century of biochemical and genetic onslaught on the embryo we are left with an inexhaustive parts list with an increasingly baroque logic. How do we begin to assemble complex living systems from knowledge of their parts list? In this talk, I will attempt to pursue a statistical (physics) approach to discerning the design principles that might be in play in developing organisms. The model system of focus will be the fruit fly's wing, within which we (in collaboration with the Carthew Lab @ NU) pursue a field-theoretic approach to studying the "response function" of the system in response to small, or linear, changes in the genome and environment that the system has evolved to cope with. The central result is an empirical delineation of the manifest degeneracies in the genotype to phenotype map, and an attempt to understand how living matter balances the apparent conflict between the requirements of a robust engineering protocol that permits its self-assembly and the ability to evolve. The hope is that this attempt of ours opens up more questions, rather than give conclusive answers on any matter, yet.

Jan 2022
5
Wed 12:15
Alison Sweeney, Yale University
Organizer: Kabir Husain ()
Jan 2022
12
Wed 12:15
Alexander Petroff, Clark University
Jan 2022
19
Wed 12:15
OPEN
Jan 2022
26
Wed 12:15
OPEN
Feb 2022
2
Wed 12:15
Irmgard Bischofberger, MIT
Organizer: Kabir Husain ()
Feb 2022
9
Wed 12:15
OPEN
Feb 2022
16
Wed 12:15
OPEN
Feb 2022
23
Wed 12:15
OPEN
Mar 2022
2
Wed 12:15
OPEN
Mar 2022
9
Wed 12:15
OPEN